Sytrinol™ - A unique and powerful ingredient for maintaining already healthy cholesterol health† The healthful effects of both bioflavonoids as well as tocotrienols have been recognized for years. Sytrinol provides a patented and well-researched combination of flavonoids derived from the peel of tangerines and tocotrienols derived palm. Within the peel of certain fruits, compounds belonging to a class of flavonoids called polymethoxylated flavones can be found. These compounds are similar in structure to flavones, but contain additional methyl groups on their ring structure, giving them the name polymethoxylated flavones – also known as PMFs. The primary PMFs present in Sytrinol are nobiletin and tangeretin. Science on PMFs dates back to the 1960s on their antioxidant properties. Specifically, with respect to cholesterol metabolism, PMFs have been shown to support normal levels of triglycerides and apolipoprotein B, the structural protein needed for the synthesis of LDLcholesterol1. Nobiletin and tangeretin have also been shown to help maintain healthy diacylglycerol acetyl transferase, an enzyme in the liver involved in the synthesis of triglycerides4. In addition to PMFs, Sytrinol contains tocotrienols derived from palm. Tocotrienols, a group of compounds belonging to the vitamin E family, have also been studied over the years for their ability to act as antioxidants and to help support cardiovascular health. Tocotrienols have been shown to support the body’s normal production of HMG-CoA reductase, the hepatic enzyme responsible for the rate limiting step in the synthesis of cholesterol3. Consequently, the combined action of the PMFs and tocotrienols contained in Sytrinol results in a powerful synergistic action to support cardiovascular health. This effect has been confirmed in both animal as well as human studies1-4.
Plant sterols are naturally occurring plant compounds that have structures similar to, yet slightly different from cholesterol. Typical plant sterols are compounds such as β-sitosterol, campesterol, and stigmasterol and can be found in vegetables, fruits, legumes, nuts, grains and certain types of oils. Research has shown that these compounds compete with the absorption of dietary cholesterol as well as inhibit the re-absorption of endogenous cholesterol in the gastrointestinal tract5. Supplementation with plant sterols can significantly lower cholesterol levels and have been shown to work synergistically with other therapies for lowering cholesterol6. Numerous foods including orange juice, rice drink, and margarine now incorporate plant sterols, or sterol esters. Increasingly, dietary supplements are now incorporating plant sterols and using the health claim that has been allowed for products containing at least 800 mg of plant sterols daily. The addition of plant sterols to Cardio-Edge® provides yet another mechanism by which already healthy cholesterol levels can be maintained.
Recent science has been focusing on the cardio protective aspects of pomegranate. These brightly colored fruits contains numerous compounds known for their antioxidant capabilities, including anthocyanidins, catechins, tannis, and gallic and ellagic acids. Research has shown that supplementation with pomegranate juice can decrease macrophage lipid accumulation, and cellular cholesterol accumulation in mice7. Recently, research in humans has confirmed a beneficial effect of consuming pomegranate juice on parameters such as LDL oxidation, blood pressure, and blood vessel health8.
The combination of Sytrinol, plant sterols, and pomegranate extract present in Cardio-Edge® results in a formula that embodies the most recent science to help maintain cardiovascular health and support already healthy cholesterol levels.
Cardio-Edge® may be a useful dietary adjunct for individuals wishing to supplement their diets with a unique formula to help support normal cholesterol and cardiovascular health.
1. James M. Roza, CN; Zheng Xian-Liu, PhD; Najla Guthrie. Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects. Alternative Therapies, Nov/Dec 2007, vol. 13, no. 6 2. Kurowska E, Manthey JA. Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. J Agric Food Chem. 2004. 52:2879-2886. 3. Parker RA, Pearce BC, Clark RW, Gordon DA, Wright JJ. Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3- hydroxy-3- methylglutaryl-coenzyme A reductase. J Biol Chem. 1993;268(15):11230-11238. 4. Kurowska EM, Manthey JA, Casaschi A, Theriault AG. Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, tangeretin. Lipids. 2004. 39:143-151. 5. Jones PJH, MacDougall DE, Ntanios F, Vanstone CA. Dietary phytosterols as cholesterol-lowering agents in humans. Can J Physiol Pharmacol. 1997. 75:217-227. 6. Nestel P, Cehun M, Pomeroy S, Abbey M, Weldon G. Cholesterol-lowering effects of plant sterol esters and nonesterified stanols in margarine, butter and low-fat foods. Eur J Clin Nutr. 2001. 55:1084-1090. 7. Kaplan M, Hayek T, Raz A, Coleman R, Dornfeld L, Vaya J, Aviram M. Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J Nutr. 2001. 131:2082-2089 8. Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfled L, Volkova N, Presser D, Attias J, Liker H, Hayek T. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr. 2004. 23:423-433.